Regarding the Layout constraints for the module, We have mouting holes in PCB near the module & for that we are planning to use nylon screws instead of metal screws.
Due to space constraint & Reliable mounting of PCB , we cannot have cutout in PCB where antenna of the module resides. But we are making sure no copper is around that area.
Kindly give your comment on it.
Attached the mouting hole location & Module location in the PCB for your reference....